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Role of tau protein in both physiological and pathological conditions.

Physiological reviews (2004-03-27)
Jesus Avila, Jose J Lucas, Mar Perez, Felix Hernandez
ABSTRACT

The morphology of a neuron is determined by its cytoskeletal scaffolding. Thus proteins that associate with the principal cytoskeletal components such as the microtubules have a strong influence on both the morphology and physiology of neurons. Tau is a microtubule-associated protein that stabilizes neuronal microtubules under normal physiological conditions. However, in certain pathological situations, tau protein may undergo modifications, mainly through phosphorylation, that can result in the generation of aberrant aggregates that are toxic to neurons. This process occurs in a number of neurological disorders collectively known as tauopathies, the most commonly recognized of which is Alzheimer's disease. The purpose of this review is to define the role of tau protein under normal physiological conditions and to highlight the role of the protein in different tauopathies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Tau-410 human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE), lyophilized powder
Sigma-Aldrich
Tau-383 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Sigma-Aldrich
Tau-412 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Sigma-Aldrich
Tau-441 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Sigma-Aldrich
Tau-352 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Sigma-Aldrich
Tau-381 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder