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Key Documents

94646

Sigma-Aldrich

Poly(ethylene glycol)

BioUltra, 35,000

Synonym(s):

Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
UNSPSC Code:
12352104
PubChem Substance ID:
NACRES:
NA.26

product line

BioUltra

form

powder or crystals (or flakes)

mol wt

Mr ~35000

impurities

insoluble matter:, passes filter test
≤0.005% peroxides (as H2O2):

pH

5.5-7.0 (25 °C, 50 mg/mL in H2O)

mp

64-66 °C

solubility

H2O: 50 mg/mL at 25 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

50 mg/mL in H2O

UV absorption

λ: 260 nm Amax: 0.12
λ: 280 nm Amax: 0.12

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Polyethylene glycol (PEG) is a polyether compound that is used as an additive in cosmetics, pharmaceuticals, and food. It consists of repeated ethylene glycol units[-(CH2CH2O)n].

Application

Poly(ethylene glycol) has been used:
  • as a component of University of Wisconsin (UW) cold preservation solutions to stabilize the cell membrane of hepatocytes during temperature changes
  • as a component of the supercooling solution to study supercooling preservation technique of the rat liver for transplantation and to protect against hypothermic injury
  • to prepare aqueous phase for the fabrication of multicellular spheroid (MCS) cultures

Biochem/physiol Actions

Polyethylene glycol (PEG) is a synthetic polymer that is used as a gold standard in bioconjugation and nanomedicine to extend blood circulation time and enhance drug efficacy. It acts as an ice-modulator by preventing ice crystallization, which is beneficial for cellular membranes. PEG provides protection against hypothermic injury, like lipid peroxidation and cell membrane injury. PEG-conjugated drugs are considered safe for use in humans and are approved by the U.S. Food and Drug Administration (FDA). PEG has several biomedical applications, including biosensing, imaging, and tissue engineering. It also repels protein adsorption and lowers the liver uptake, which helps in coating nanoparticles.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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