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Key Documents

74595

Supelco

(±)-Glycidol

analytical standard

Synonym(s):

(±)-Oxirane-2-methanol, 2,3-Epoxy-1-propanol, Glycerolglycide

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About This Item

Empirical Formula (Hill Notation):
C3H6O2
CAS Number:
Molecular Weight:
74.08
Beilstein:
383562
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

vapor density

2.15 (vs air)

vapor pressure

0.9 mmHg ( 25 °C)

Assay

≥95.0% (GC)

autoignition temp.

780 °F

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.429-1.437
n20/D 1.433 (lit.)

bp

61-62 °C/15 mmHg (lit.)

density

1.117 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

SMILES string

OCC1CO1

InChI

1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2

InChI key

CTKINSOISVBQLD-UHFFFAOYSA-N

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General description

Glycidol is an aliphatic epoxide which may be used as a stabilizer in the manufacture of vinyl polymers, as an additive for oil and synthetic hydraulic fluids, and also as a diluent in some epoxy resins.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

161.6 °F

Flash Point(C)

72 °C


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Carcinogenicity of glycidol in F344 rats and B6C3F1 mice.
Irwin RD, et al.
Journal of Applied Toxicology, 16(3), 201-209 (1996)
NTP Toxicology and Carcinogenesis Studies of Glycidol (CAS No. 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies).
National Toxicology Program and others
National Toxicology Program Technical Report Series, 374(3), 1-1 (1990)
Hirotoshi Akane et al.
Journal of applied toxicology : JAT, 34(12), 1389-1399 (2014-01-08)
We previously found that exposure to glycidol at 1000 ppm in drinking water caused axonopathy in maternal rats and aberrations in late-stage hippocampal neurogenesis, targeting the process of neurite extension in offspring. To identify the profile of developmental neurotoxicity of
Glycidol.
IARC monographs on the evaluation of carcinogenic risks to humans, 77, 469-486 (2000-12-02)
B D Craft et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(1), 46-51 (2012-10-02)
Recently, fatty acid esters of monochloropropanediol (MCPD) and that of glycidol have been reported in refined edible oils. Since then a wealth of research has been published on the factors influencing the formation of these contaminants in foods. It can

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