E-001

Ecgonine methyl ester solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): Ecgonine methyl ester solution
• Empirical Formula (Hill Notation): C₁₀H₁₇NO₃
• CAS Number: 7143-09-1
• Molecular Weight: 199.25
• EC Number: 200-835-2
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
• concentration: 1.0 mg/mL in acetonitrile
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• InChI: 1S/C10H17NO3/c1-11-6-3-4-7(11)9(8(12)5-6)10(13)14-2/h6-9,12H,3-5H2,1-2H3/t6?,7?,8-,9+/m0/s1
• InChI key: QIQNNBXHAYSQRY-ABIFROTESA-N

Description

General description

A certified Snap-N-Spike^® solution standard suitable for use in LC/MS or GC/MS testing applications including forensic analysis, urine drug testing, and clinical toxicology. Ecgonine methyl ester is a major urinary metabolite of cocaine, a popular illicit drug well known as "crack" or the free base form of cocaine that can be smoked.

Application

• Ecgonine methyl ester standard:The site- and species-specific hydrolysis rates of cocaine, demonstrating the importance of Ecgonine methyl ester as a reference standard in understanding cocaine metabolism pathways, aiding in pharmaceutical and forensic applications (Szocs et al., 2017).


• Mass spectrometry reagent:Sensitive fluorescence probe was developed using molecularly imprinted polymers and Mn-doped ZnS quantum dots for the determination of cocaine and metabolites in urine, highlighting the use of Ecgonine methyl ester as a crucial mass spectrometry reagent for drug testing (Chantada-Vazquez et al., 2016).


• Cocaine metabolite analysis:Magnetic molecularly imprinted polymers were developed for solid phase extraction of cocaine and metabolites in urine before high-performance liquid chromatography - tandem mass spectrometry, illustrating the essential role of Ecgonine methyl ester in the selective detection and quantification of cocaine metabolites (J Sanchez-Gonzzlez, et al., 2016).


• Biochemical research chemicals:Porous membrane-protected molecularly imprinted polymer micro-solid-phase extraction method for analyzing urinary cocaine and its metabolites, validating Ecgonine methyl ester′s utility in biochemical and pharmacological studies (Sanchez-Gonzalez et al., 2015).


• Forensic toxicology supplies:Employed peptides to trap cocaine, using solid phase extraction followed by liquid chromatography-mass spectrometry in plasma samples, underlining the application of Ecgonine methyl ester in forensic toxicology for precise and accurate drug monitoring (Mascini et al., 2013).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2 °C - closed cup