SAB5600047

Anti-BRAF (V600E) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM8, purified immunoglobulin

• Synonym(s): Anti-B-RAF1, Anti-B-raf, Anti-BRAF-1, Anti-BRAF1, Anti-NS7, Anti-RAFB1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• recombinant: expressed in HEK 293 cells
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: RM8, monoclonal; recombinant monoclonal
• form: buffered aqueous glycerol solution
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 0.5-2 μg/mL; immunoblotting: 0.5-2 μg/mL; immunocytochemistry: 0.5-5 μg/mL; immunohistochemistry: 0.5-5 μg/mL
• isotype: IgG
• NCBI accession no.: 673
• UniProt accession no.: P15056
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... BRAF(673)

Description

General description

BRAF (B-Raf proto-oncogene) is a serine-threonine kinase, that codes for B-Raf protein. It is located on human chromosome 7q34.

Specificity

This antibody reacts to the BRAF V600E mutant. No cross reactivity with wild type BRAF.

Immunogen

Peptide corresponding to BRAF V600E mutant

Biochem/physiol Actions

BRAF (B-Raf proto-oncogene) participates in signaling direct cell growth. It induces tumor growth by initiating the mitogen-activated protein kinase (MAPK) pathway in various tumors like cutaneous melanoma and carcinomas of the thyroid and colon.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable