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SAB4200713

Sigma-Aldrich

Anti-Human IgG (γ-chain specific) antibody, Mouse monoclonal

clone GG-5, purified from hybridoma cell culture

Synonym(s):

Mouse Anti-Human IgG (γ-chain specific)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

GG-5, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

indirect ELISA: 0.25-0.5 μg/mL using 5μg/mL human IgG for coating

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

Anti-Human IgG (γ-chain specific) antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the GG-5 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with purified human IgG. Immunoglobulins (Igs) are produced by B lymphocytes and secreted into the plasma. Immunoglobulins can be divided into five main classes/isotypes which are IgA, IgD, IgE, IgG, and IgM. IgG class identity is determined by class-specific sequences in the Fc region of the heavy chain. IgG antibody class are the most abundant immunoglobulins isotype in blood, lymph fluid, cerebrospinal fluid and peritoneal fluid. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4). The IgG subclasses differ in their physical and chemical properties. Their distribution pattern is found to be age dependent and every subclass has a specific biological function.

Immunogen

purified human IgG

Application

Anti-Human IgG (γ-chain specific) antibody, Mouse monoclonal has been used in indirect ELISA.

Biochem/physiol Actions

Immunoglobulins (Igs) serve as key players in the humoral immune response.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These

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