Skip to Content
Merck
All Photos(5)

Documents

G6752

Sigma-Aldrich

Guanosine

≥98%

Synonym(s):

9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C10H13N5O5
CAS Number:
Molecular Weight:
283.24
Beilstein:
625911
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

biological source

microbial

Quality Level

Assay

≥98%

form

powder

mp

250 °C (dec.) (lit.)

solubility

formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

SMILES string

[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1

InChI key

NYHBQMYGNKIUIF-UUOKFMHZSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Application

Guanosine has been used:
  • as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
  • as a component of Mouse Embryonic Fibroblasts (MEFs) culture
  • as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC

Biochem/physiol Actions

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury
Kelly KJ, et al.
The Journal of Clinical Investigation, 108(9), 1291-1298 (2001)
Guanosine: a neuromodulator with therapeutic potential in brain disorders
Lanznaster D, et al.
Aging and disease, 7(5), 657-657 (2016)
mTORC1 couples nucleotide synthesis to nucleotide demand resulting in a targetable metabolic vulnerability
Valvezan AJ, et al.
Cancer Cell, 32(5), 624-638 (2017)
Qualitative and quantitative analysis of glucosinolates and nucleosides in Radix Isatidis by HPLC and liquid chromatography tandem mass spectrometry
Wang X, et al.
Acta Pharmaceutica Sinica. B, 3(5), 337-344 (2013)
Guanosine and its role in neuropathologies
Bettio LEB, et al.
Purinergic Signaling, 12(3), 411-426 (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service