Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

85588

Supelco

Spermine dihydrate

BioUltra, ≥99.5% (GC)

Synonym(s):

Gerontine, Musculamine, N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Neuridine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2 · 2H2O
CAS Number:
403982-64-9
Molecular Weight:
238.37
Beilstein:
7526933
EC Number:
200-754-2
MDL number:
MFCD01459904
UNSPSC Code:
12000000
PubChem Substance ID:
329769391
NACRES:
ND.02

product line

BioUltra

Quality Level

100

Assay

≥99.5% (GC)

form

powder

impurities

insoluble matter, passes filter test

pH

12.0-13.5 (25 °C, 1 M in H2O)

mp

63-64 °C

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.20
λ: 280 nm Amax: 0.20

storage temp.

2-8°C

SMILES string

O.O.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.2H2O/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;/h13-14H,1-12H2;2*1H2

InChI key

MTNRSMVAYLLBAV-UHFFFAOYSA-N

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Other Notes

Polyamines: Review; Inhibitor of ATPase; DNA polymerase; ribonuclease

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCG7438
BCBR2118V
1427249
1427249V
1302895

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Y Tashima et al.
Biochimica et biophysica acta, 482(1), 1-10 (1977-05-12)
Specific inhibition of ouabain-sensitive and K+-dependent p-nitrophenyl-phosphatase activity of rabbit kidney plasma membranes by spermine (N,N'-bis(3-aminopropyl)-1,4-butanediamine) was characterized kinetically. 1. Inhibition by spermine was competitive with K+. The Ki for spermine was 31 micronM in the presence of 1 mM
Effect of polyamines on a ribonuclease which hydrolyzes ribonucleic acid at uridylic acid residues.
C C Levy et al.
The Journal of biological chemistry, 248(16), 5712-5719 (1973-08-25)
Ca++ uptake in muscle microsomes. Activation by polyamines.
L De Meis
The Journal of biological chemistry, 243(6), 1174-1179 (1968-03-25)
Dean Frawley et al.
Fungal genetics and biology : FG & B, 140, 103396-103396 (2020-04-24)
The ubiquitin proteasome system is critical for the regulation of protein turnover, which is implicated in the modulation of a wide array of biological processes in eukaryotes, ranging from cell senescence to virulence in plant and human hosts. Proteins to
J D Karkas et al.
The Journal of biological chemistry, 250(22), 8657-8663 (1975-11-25)
The more than 2,300-fold purification of a DNA polymerase from the embryos of Drosophila melanogaster is described. The enzyme, which forms a single band on gel electrophoresis, has a molecular weight of about 87,000 and a pH optimum of 8.5.
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service