A0233

AS605240

≥98% (HPLC)

• Synonym(s): 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
• Empirical Formula (Hill Notation): C₁₂H₇N₃O₂S
• CAS Number: 648450-29-7
• Molecular Weight: 257.27
• MDL number: MFCD11100415
• UNSPSC Code: 12352200
• PubChem Substance ID: 329770591
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: , faint red to orange to dark brown
• solubility: DMSO: 1 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O=C1NC(=O)C(\S1)=C\c2ccc3nccnc3c2
• InChI: 1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-
• InChI key: SQWZFLMPDUSYGV-POHAHGRESA-N

Description

Application

AS605240 has been used:

• as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
• as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
• as a class 1A PI3K inhibitor to treat CD4⁺ T cells.

Biochem/physiol Actions

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.

AS605240 is a potent and selective PI3Kγ inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves