Skip to Content
Merck
All Photos(1)

Key Documents

324744-M

Sigma-Aldrich

Elastase Inhibitor II

The Elastase Inhibitor II controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Elastase Inhibitor II, HNE Inhibitor, MeOSuc-AAPA-CMK, MSACK

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C20H31ClN4O7
Molecular Weight:
474.94
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥99% (TLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 10 mg/mL
methanol: soluble

storage temp.

−20°C

General description

A potent inhibitor of human neutrophil elastase (HNE).The inhibition results from cross-linking of catalytic residues His57 and Ser195 in the HNE in the presence of this inhibitor.
A potent irreversible inhibitor of human neutrophil elastase (HNE). Inhibition results from cross-linking of the catalytic residues His57 and Ser195.

Biochem/physiol Actions

Primary Target
Human neutrophil elastase (HNE)

Warning

Toxicity: Standard Handling (A)

Sequence

MeOSuc-Ala-Ala-Pro-Ala-CMK

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Navia, M.A., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 7.
Williams, H.R., et al. 1987. J. Biol. Chem.262, 17178.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service