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  • Biological exposure indicators: quantification of biological variability using toxicokinetic modeling.

Biological exposure indicators: quantification of biological variability using toxicokinetic modeling.

Journal of occupational and environmental hygiene (2006-02-09)
Ginette Truchon, Robert Tardif, Pierre-Olivier Droz, Ginette Charest-Tardif, Guillaume Pierrehumbert
ABSTRACT

Compartmental and physiologically based toxicokinetic modeling coupled with Monte Carlo simulation were used to quantify the impact of biological variability (physiological, biochemical, and anatomic parameters) on the values of a series of bio-indicators of metal and organic industrial chemical exposures. A variability extent index and the main parameters affecting biological indicators were identified. Results show a large diversity in interindividual variability for the different categories of biological indicators examined. Measurement of the unchanged substance in blood, alveolar air, or urine is much less variable than the measurement of metabolites, both in blood and urine. In most cases, the alveolar flow and cardiac output were identified as the prime parameters determining biological variability, thus suggesting the importance of workload intensity on absorbed dose for inhaled chemicals.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Methyl-2-pentanone, ≥99%, FCC
Sigma-Aldrich
4-Methyl-2-pentanone, ACS reagent, ≥98.5%
Sigma-Aldrich
4-Methyl-2-pentanone, ≥99%
Sigma-Aldrich
4-Methyl-2-pentanone, suitable for HPLC, ≥99.5%
Supelco
4-Methyl-2-pentanone, analytical standard