SML0307

Pleconaril

≥98% (HPLC)

• Synonym(s): 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole, VP 63843, Win 63843
• Empirical Formula (Hill Notation): C₁₈H₁₈F₃N₃O₃
• CAS Number: 153168-05-9
• Molecular Weight: 381.35
• MDL number: MFCD00923611
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825312
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥10 mg/mL (warmed)
• storage temp.: room temp
• SMILES string: Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1
• InChI: 1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
• InChI key: KQOXLKOJHVFTRN-UHFFFAOYSA-N

Description

General description

Pleconaril is a drug, that has antiviral activity.

Application

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

Biochem/physiol Actions

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.

Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. Also, pleconaril delays the onset of diabetes in experimental animals infected with Ljungan virus (LV).

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H413
• Precautionary Statements: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable