SAB4300461

Anti-RAC1 (Ab-71) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-MGC111543 antibody produced in rabbit, Anti-MIG5 antibody produced in rabbit, Anti-TC-25 antibody produced in rabbit, Anti-p21-Rac1 antibody produced in rabbit, Anti-ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) antibody produced in rabbit
• MDL number: MFCD01322704
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~28 kDa
• species reactivity: mouse, rat, human
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (P-L-S-Y-P)
• NCBI accession no.: NP_008839.2
• UniProt accession no.: P63000
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... RAC1(5879)

Description

General description

RAC1 (ras-related C3 botulinum toxin substrate 1) is a polarity related protein , that belongs to the Rho family of small guanosine triphosphatases. It is located on human chromosome 7p22.

Immunogen

Peptide sequence around aa. 69-73 (P-L-S-Y-P), according to the protein RAC1.

Application

Anti-RAC1 (Ab-71) antibody has been used in western blot analysis .

Biochem/physiol Actions

RAC1 (ras-related C3 botulinum toxin substrate 1) plays a major role in cancer invasion and metastasis. It can be considered as a therapeutic target for breast cancer. It is essential for several cellular activities like phagocytosis, adhesion, migration, motility, cell proliferation and axonal growth.

Features and Benefits

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Target description

Rac1 encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable