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Key Documents

G6910

Supelco

Ginkgolide B from Ginkgo biloba leaves

≥90% (HPLC)

Synonym(s):

BN-52021

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About This Item

Empirical Formula (Hill Notation):
C20H24O10
CAS Number:
Molecular Weight:
424.40
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

Assay

≥90% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

−20°C

SMILES string

C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]36[C@@H](O)C(=O)O[C@H]6O[C@@]4(C(=O)O5)[C@@]12O

InChI

1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17+,18+,19-,20-/m1/s1

InChI key

SQOJOAFXDQDRGF-MMQTXUMRSA-N

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General description

Ginkgolide B from Ginkgo biloba leaves is a terpene lactone and one of the main molecular form of ginkgolides, present in Ginkgo biloba leaves. It is widely used to treat peripheral and cerebral circulation disorders.

Application

Ginkgolide B from Ginkgo biloba leaves is used as an analytical reference standard:
  • For the chromatographic separation of the analyte in Ginkgo biloba leaves extract and to study the antimicrobial activity exerted on a variety of Gram-positive and -negative bacteria and yeasts.
  • For the determination of the analyte in Ginkgo biloba L. phytopharmaceuticals using high-performance liquid chromatography technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Primary constituent of Ginkgo biloba. Potential anticancer agent and neuroprotective.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Antimicrobial investigation of semi-purified fractions of Ginkgo biloba leaves
Mazzanti.G, et al.
Journal of Ethnopharmacology, 71(1-2), 83-88 (2005)
Yuan Yuan et al.
Journal of chromatographic science, 51(3), 266-272 (2012-08-31)
A sensitive, simple and rapid liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of ginkgolide B (GB) and the prodrug of ginkgolide B (PGB) in rat plasma and brain tissue. Detection was performed on a
Gianni Allais et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 33 Suppl 1, S111-S115 (2012-06-01)
Premenstrual syndrome (PMS) includes a wide variety of physical, psychological, and cognitive symptoms that occur recurrently and cyclically during the luteal phase of the menstrual cycle and disappear soon after the onset of menstruation. Headache, often of migrainous type, is
Shi-hai Xia et al.
Chinese medical journal, 120(10), 922-928 (2007-06-05)
To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating
Yuna Cui et al.
Fitoterapia, 83(5), 913-920 (2012-04-28)
To screen the presence of ginkgolide B-producing endophytic fungi from the root bark of Ginkgo biloba, a total of 27 fungal isolates, belonging to 6 different genus, were isolated from the internal root bark of the plant Ginkgo biloba. The

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