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Key Documents

ABE1081

Sigma-Aldrich

Anti-JMJD2E/KDM4E Antibody

serum, from rabbit

Synonym(s):

Lysine-specific demethylase 4E, KDM4D-like protein, Lysine-specific demethylase 4D-like, JMJD2E

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, rat, human

technique(s)

western blot: suitable

NCBI accession no.

XP_004052044

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KDM4E(390245)

General description

Histone N(ϵ)-methyl lysine demethylases are important in epigenetic regulation. JMJD2E (KDM4E) also known as Lysine-specific demethylase 4E, histone lysine demethylase 4E, or KDM4D-like protein, and encoded by the gene KDM4E/KDM4DL, is a member of the large Fe(II)/2-oxoglutarate- dependent family of human histone demethylases. JMJD2E (KDM4E) is a histone demethylase that specifically demethylates ′Lys-9′ of histone H3, thereby playing a central role in histone code. The KDM4 family also includes KDM4A, KDM4B, KDM4C, and KDM4D. These are also referred to as JMDM3A/JMJD2A, JMDM3B/JMJD2B, JMDM3C/JMJD2C, and JMDM3D/JMJD2D, respectively. Steady-state assays showed that KDM4E has a graded response to O2 over a physiologically relevant range of O2 concentrations, with activity level being dependent upon the methylation status of the target protein, and research with JMJD2E(KDM4E) may indicate the potential for histone demethylase activity to be regulated by oxygen availability.

Immunogen

Linear peptide corresponding to JMJD2E/KDM4E.

Application

Detect JMJD2E/KDM4E using this Anti-JMJD2E/KDM4E antibody validated for use in western blotting.

Quality

Evaluated by Western Blotting in PC-12 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected JMJD2E/KDM4E in 10 µg of PC-12 cell lysate.

Target description

~65 kDa observed

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Jingyi Li et al.
Nature communications, 13(1), 1172-1172 (2022-03-06)
Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple stressors. However, the mechanisms underlying autophagy initiation upon hypoxia remains unclear. Here we show that protein

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