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222801

Sigma-Aldrich

4-Nitrobenzyl chloroformate

97%, for peptide synthesis

Synonym(s):

(4-Nitrophenyl)methyl carbonochloridate, (4-Nitrophenyl)methyl chloroformate, 4-Nitrobenzyloxycarbonyl chloride, p-Nitrobenzyloxycarbonyl chloride, p-nitrobenzyl chloroformate

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About This Item

Linear Formula:
ClCO2CH2C6H4NO2
CAS Number:
4457-32-3
Molecular Weight:
215.59
Beilstein:
912446
EC Number:
224-708-6
MDL number:
MFCD00007375
UNSPSC Code:
12352101
PubChem Substance ID:
24853356
NACRES:
NA.22

product name

4-Nitrobenzyl chloroformate, 97%

Assay

97%

reaction suitability

reaction type: Carbonylations

mp

32-34 °C (lit.)

application(s)

peptide synthesis

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(COC(Cl)=O)cc1

InChI

1S/C8H6ClNO4/c9-8(11)14-5-6-1-3-7(4-2-6)10(12)13/h1-4H,5H2

InChI key

MHSGOABISYIYKP-UHFFFAOYSA-N

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Related Categories

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H335

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Eun Hyang Jang et al.
International journal of pharmaceutics, 580, 119237-119237 (2020-03-24)
Hypoxia is a characteristic feature of various ischemic diseases, including cancer. This study describes the development of glycol chitosan nanoparticles, hydrophobically modified with 4-nitrobenzyl chloroformate and folic acid (FA), that can specifically release drugs under hypoxic conditions. This hypoxia-responsive glycol

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