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  • SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells.

SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells.

FEBS letters (2020-08-09)
Ferran Medina-Jover, Núria Gendrau-Sanclemente, Francesc Viñals
ABSTRACT

BMP9 is a cytokine involved in the maturation phase of the angiogenic process that signals through its serine/threonine receptor ALK1 and its coreceptor endoglin. In this paper, we explain how BMP9 directs the regulation of endothelial cell proliferation blockage while in turn stimulating protein synthesis. To achieve this, BMP9 promotes SGK1 synthesis and activation through mTORC2 in order to stimulate the mTORC1/S6K/S6 axis. Moreover, BMP9 blocks proliferation also through SGK1 by reducing the activity of the MEK/ERK signalling pathway. Inhibition of SGK1 activity is sufficient to prevent BMP9-mediated inhibition of ERK, leading to an increase in endothelial cell proliferation. Overall, our findings reveal that SGK1 is a key player during angiogenesis, mediating the pro-quiescent and maturation effects of BMP9/ALK1.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Monoclonal Anti-Vinculin antibody produced in mouse, clone hVIN-1, ascites fluid
Sigma-Aldrich
GSK-650394, ≥98% (HPLC)
Sigma-Aldrich
MISSION® esiRNA, targeting human SGK1