372846
Poly(2-ethyl-2-oxazoline) 5-7 cSt
Synonym(s):
Poly(2-ethyl-2-oxazoline), PEOX, POx, PetOx, poly 2-ethyloxazoline, polyethyloxazoline
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All Photos(3)
About This Item
Linear Formula:
[-N(COC2H5)CH2CH2-]n
CAS Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
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form
solid
mol wt
average Mw ~50,000
refractive index
n20/D 1.52
viscosity
5-7 cSt, 10 % in water(100 °F)
transition temp
softening point 110-120 °C (Vicat, ASTM D 1525-82)
Tg 69-71 °C
density
1.14 g/mL at 25 °C (lit.)
PDI
3‑4
InChI
1S/C5H9NO/c1-2-5-6-3-4-7-5/h2-4H2,1H3
InChI key
NYEZZYQZRQDLEH-UHFFFAOYSA-N
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Application
This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation.
Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Adhesion promoter in coatings. Heat sealing and remoistenable hot-melt adhesive
Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Adhesion promoter in coatings. Heat sealing and remoistenable hot-melt adhesive
Features and Benefits
Nonionic, water-soluble thermoplastic. Better heat stability than poly(vinyl alcohol). Good melt flow, shear stability and Newtonian characteristics. Water is a room temperature Theta solvent.
Physical form
N-propionyl substituted linear polyethylenimine
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Yung-Chu Chen et al.
Journal of biomedical materials research. Part A, 100(5), 1279-1292 (2012-03-01)
The multifunctional nanoparticles constructed from triphenylamine-poly(lactide-co-glycolide)-poly(ethyleneglycol)-poly(lactide-co-glycolide) (TPA-PEP) and folate-poly(2-ethyl-2oxazoline)-poly(D,L-lactide) (folate-PEOz-PLA) were developed in this study. Iron oxide nanoparticles (IOP) and paclitaxel (PTX) were coencapsulated in the nanoparticles with diameter less than 200 nm. The drug-loaded nanoparticles emit fluorescence peak at
I C Kwon et al.
Nature, 354(6351), 291-293 (1991-11-28)
New controlled drug-delivery systems are being explored to overcome the disadvantages of conventional dosage forms. For example, stimulated drug-delivery has been used to overcome the tolerance problems that occur with a constant delivery rate, to mimic the physiological pattern of
Chau-Hui Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(1), 140-149 (2005-09-27)
Polymeric micelles based on poly(L-lactide)-b-poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PLLA-PEOz-PLLA) ABA triblock copolymers were designed as intracellular drug carriers. The PLLA-PEOz-PLLA micelles adopt a "flower-like" arrangement with A-blocks at the core and a B-block on the shell under neutral condition. The deformation of the
Chau-Hui Wang et al.
Biomacromolecules, 4(6), 1487-1490 (2003-11-11)
A new series of cationic, thermo-sensitive, and biodegradable poly(L-lactide)-poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PLLA-PEOz-PLLA) triblock copolymers were synthesized by ring-opening polymerization. With increasing molecular weight and crystallinity of hydrophobic PLLA blocks, the critical micellization concentrations (CMC) occurred at lower concentration. The PLLA-PEOz-PLLA aqueous solution
Issa Katime et al.
Applied spectroscopy, 57(7), 829-834 (2003-12-09)
This paper reports an FT-IR study of blends of poly(mono-n-alkyl itaconates) with poly(N,N-dimethylacrylamide) (PDMA) and poly(ethyloxazoline) (PEOX). Strong hydrogen bonding has been found, and both polybases have shown similar acceptor strengths. Derivative techniques show asymmetric profiles for the free carbonyl
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