- Adipose- and bone marrow-derived mesenchymal stem cells display different osteogenic differentiation patterns in 3D bioactive glass-based scaffolds.
Adipose- and bone marrow-derived mesenchymal stem cells display different osteogenic differentiation patterns in 3D bioactive glass-based scaffolds.
Journal of tissue engineering and regenerative medicine (2013-12-21)
Subha N Rath, Patcharakamon Nooeaid, Andreas Arkudas, Justus P Beier, Leonie A Strobel, Andreas Brandl, Judith A Roether, Raymund E Horch, Aldo R Boccaccini, Ulrich Kneser
PMID24357645
ABSTRACT
Mesenchymal stem cells can be isolated from a variety of different sources, each having their own peculiar merits and drawbacks. Although a number of studies have been conducted comparing these stem cells for their osteo-differentiation ability, these are mostly done in culture plastics. We have selected stem cells from either adipose tissue (ADSCs) or bone marrow (BMSCs) and studied their differentiation ability in highly porous three-dimensional (3D) 45S5 Bioglass®-based scaffolds. Equal numbers of cells were seeded onto 5 × 5 × 4 mm