- Iron halide-mediated regio- and stereoselective halosulfonylation of terminal alkynes with sulfonylhydrazides: synthesis of (E)-β-chloro and bromo vinylsulfones.
Iron halide-mediated regio- and stereoselective halosulfonylation of terminal alkynes with sulfonylhydrazides: synthesis of (E)-β-chloro and bromo vinylsulfones.
The Journal of organic chemistry (2013-08-28)
Xiaoqing Li, Xinhua Shi, Mingwu Fang, Xiangsheng Xu
PMID23978040
ABSTRACT
Halosulfonylation of terminal alkynes was achieved with sulfonylhydrazides as the sulfonyl precursor and inexpensive iron halide as halide source in the presence of TBHP, allowing the regio- and stereoselective generation of (E)-β-chloro and bromo vinylsulfones.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Iron(III) chloride hexahydrate, puriss. p.a., ACS reagent, crystallized, 98.0-102% (RT)