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Merck

2,6-Dimethylphenol: a new metabolite of mexiletine.

Research communications in chemical pathology and pharmacology (1987-10-01)
O Grech-Bélanger, J Turgeon, M Lalande
PMID3432733
ABSTRACT

A new metabolite, 2,6-dimethylphenol obtained by O-dealkylation of mexiletine by rabbit liver was identified. A g.c.-f.i.d. method was developed for its analysis in hepatic homogenates and some of the characteristics of the metabolic reaction were studied. Formation of 2,6-dimethylphenol is microsomal and is optimal under aerobic conditions. Both carbon monoxide and n-octylamine significantly depress this O-dealkylation reaction.

MATERIALS
Product Number
Brand
Product Description
W324906
Sigma-Aldrich
2,6-Xylenol, ≥99%, FG
36715
Supelco
2,6-Dimethylphenol, PESTANAL®, analytical standard
D175005
Sigma-Aldrich
2,6-Dimethylphenol, 99%
D174904
Sigma-Aldrich
2,6-Dimethylphenol, ≥99.5%