- Solubilisation of drugs in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide.
Solubilisation of drugs in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide.
International journal of pharmaceutics (2008-04-18)
Michael Crothers, Nagíla M P S Ricardo, Frank Heatley, S Keith Nixon, David Attwood, Colin Booth
PMID18417305
ABSTRACT
The solubilisation of two poorly soluble drugs, furosemide and nabumetone, in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide has been studied at 25 and 37 degrees C and solubilisation capacities compared with published values for griseofulvin and docetaxel. Solubilisation in the micelle core, corrected for the different proportions of poly(styrene oxide) in the copolymers, was similar for all four drugs. The highest solubilisation capacities were found for a copolymer with worm-like micelles.