- New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones.
New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones.
Bioorganic & medicinal chemistry letters (2003-11-19)
Upinder Singh, B Raju, Stuart Lam, Joseph Zhou, Robert C Gadwood, Charles W Ford, Gary E Zurenko, Ronda D Schaadt, Sara E Morin, Wade J Adams, Janice M Friis, Maria Courtney, Joe Palandra, Corinne J Hackbarth, Sara Lopez, Charlotte Wu, Kathleen H Mortell, Joaquim Trias, Zhengyu Yuan, Dinesh V Patel, Mikhail F Gordeev
PMID14623003
ABSTRACT
Combinatorial libraries of N-acylated 5-(S)-aminomethyloxazolidinone derivatives of S-oxide and S,S-dioxide tetrahydro-4(2H)-thiopyranyl and thiomorpholine phenyloxazolidinone series have been synthesized on a solid phase and evaluated for antimicrobial activity. Several novel potent leads have been identified, including orally active oxazolidinones with enhanced activity against respiratory tract infection pathogens Haemophilus influenzae and Moraxella catarrhalis.
MATERIALS