BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.

BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.

Antimicrobial agents and chemotherapy (2007-09-26)

Parmjeet Randhawa, Noush Afarin Farasati, Yuchen Huang

ABSTRACT

BK virus is an important pathogen in kidney transplant recipients. In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development.

MATERIALS

Product Number

Brand

Product Description

O9882

Sigma-Aldrich

Octyl β-D-glucopyranoside, BioXtra, ≥98% (GC)

O8001

Sigma-Aldrich

Octyl β-D-glucopyranoside, ≥98% (GC)

N7507

Sigma-Aldrich

Nonyl β-D-glucopyranoside, ≥97.0% (GC)

O3757

Sigma-Aldrich

Octyl β-D-glucopyranoside solution, ≥95% (HPLC), 50 % (w/v) in H₂O

M6882

Sigma-Aldrich

Methyl α-D-mannopyranoside, ≥99.0% (HPLC)

C9754

Sigma-Aldrich

Colchicine, ≥95% (HPLC), powder

C3915

Sigma-Aldrich

Colchicine, BioReagent, suitable for plant cell culture, ≥95% (HPLC)

18842

Sigma-Aldrich

Octyl-β-D-glucopyranoside 100 mM solution

67770

Millipore

Methyl α-D-mannopyranoside, ≥99.0%, suitable for microbiology, enables differentiation between species of Listeria