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S7023

Sigma-Aldrich

Sera human

frozen liquid

Synonym(s):

Human Blood Serum, Human Serum

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About This Item

UNSPSC Code:
12352207
NACRES:
NA.71

biological source

human

Quality Level

form

frozen liquid

origin

USA origin

shipped in

dry ice

storage temp.

−20°C

General description

The serum is the fluid from plasma devoid of fibrinogen, prothrombin, and other clotting factors. It contains various plasma proteins, amino acids, polypeptides, growth factors, fat, carbohydrates, nucleic acid derivatives, hormones, inorganic minerals, and vitamins.

Application

Sera human has been used:
  • to prepare the antigen standards for the validation assay of multiple-biomarker detection
  • as a quality check (QC) sample to optimize the experimental workflow
  • as a control in immunoproteomics assay

Biochem/physiol Actions

Human serum is used as a cell culture supplement. It maintains physiological balance by stimulating or inhibiting cell growth. It is known to have an inhibitory action on endogenous and exogenous enzymes.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Josep Villanueva et al.
Nature protocols, 1(2), 880-891 (2007-04-05)
Blood is a convenient source of biomarkers. Readily obtainable, it immerses most tissues in the body and is therefore likely to contain cell-derived proteins and peptides that may provide information about various biological processes. Serum proteome and peptidome profiling--using mass
Maegan E Boutot et al.
Metabolites, 11(10) (2021-10-23)
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this
Qin Fu et al.
Methods in molecular biology (Clifton, N.J.), 357, 365-371 (2006-12-19)
Serum is a readily available source for diagnostic assays, but the identification of disease-specific serum biomarkers has been impeded by the dominance of human serum albumin (HSA) and immunoglobulin G (IgG) in the serum proteome. Therefore, in order to observe
Matthew J Dorman et al.
mBio, 9(6) (2018-11-22)
Klebsiella pneumoniae infections affect infants and the immunocompromised, and the recent emergence of hypervirulent and multidrug-resistant K. pneumoniae lineages is a critical health care concern. Hypervirulence in K. pneumoniae is mediated by several factors, including the overproduction of extracellular capsule.
Amandine Buffet et al.
Proceedings. Biological sciences, 288(1946), 20202876-20202876 (2021-03-04)
The fitness cost associated with the production of bacterial capsules is considered to be offset by the protection provided by these extracellular structures against biotic aggressions or abiotic stress. However, it is unknown if the capsule contributes to fitness in

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