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G8146

Sigma-Aldrich

Disialoganglioside GD1b from bovine brain

~95%, lyophilized powder

Synonym(s):

Ganglioside GD1b, disialo

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About This Item

CAS Number:
19553-76-5
MDL number:
MFCD00466941
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

~95%

Quality Level

200

form

lyophilized powder

storage temp.

−20°C

InChI

1S/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

InChI key

AIUBMTQAHKTQMI-MPGPKOMUSA-N

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Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Attarian et al.
Journal of neurology, neurosurgery, and psychiatry, 81(1), 61-64 (2009-09-04)
To determine the responses to treatment of patients with chronic sensory ataxic neuropathy associated with anti-GD1b IgM antibodies. Patients with chronic sensory ataxic neuropathy associated with anti-GD1b IgM antibodies followed in our department for at least 12 months between 2001
S Tellier et al.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 19(1), 51-54 (2011-12-14)
We describe the case of a 10-year-old child with the acute motor axonal neuropathy (AMAN) form of Guillain-Barré syndrome (GBS) with preserved tendon reflexes, 6 days after a bout of gastroenteritis. The child quickly showed weakness of the distal muscles
An unusual presentation of Guillain-Barré syndrome associated with monospecific anti-GD1b antibodies.
Maarten Dewil et al.
Journal of neurology, neurosurgery, and psychiatry, 81(5), 587-588 (2010-05-13)
Beatriz Valle-Argos et al.
Neuro-oncology, 12(11), 1135-1146 (2010-07-10)
In spite of their low incidence, central nervous system tumors have elevated morbidity and mortality, being responsible for 2.3% of total cancer deaths. The ganglioside O-acetylated GD1b (O-Ac GD1b; neurostatin), present in the mammalian brain, and the semi-synthetic O-butyrylated GD1b
Seong-Hae Jeong et al.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 31(4), 326-330 (2011-09-16)
Antiganglioside antibodies are found in various neurological disorders that constitute a continuum from peripheral neuropathy to encephalitis. However, nystagmus has rarely been described in patients with ataxia associated with antiganglioside antibodies. From January 2008 to July 2009, we identified 3
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