A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• Synonym(s): 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• Empirical Formula (Hill Notation): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• CAS Number: 160928-38-1
• Molecular Weight: 785.05 (anhydrous basis)
• MDL number: MFCD12910436
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278252
• NACRES: NA.77

Properties

• product name: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: H₂O: >20 mg/mL; DMSO: insoluble
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• InChI key: UWMONIJVKGTUGE-OPKBHZIBSA-K
• Gene Information: human ... ENTPD2(954)

Description

General description

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39. This ecto-ATPase inhibitor is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

Application

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay

Biochem/physiol Actions

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3