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14-304

Sigma-Aldrich

MKK6/SKK3 Protein, inactive, 50 g

Unactive, recombinant human MKK6, amino acids 4-end, fused at the N-terminus to a Mal-E tag, for use in Kinase Assays.

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli

mol wt

Mw 80.6 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

human ... MAP2K6(5608)

General description

Product Source: expressed in E. coli
Recombinant human MKK6, amino acids 4-end, fused at the N-terminus to a Mal-E tag

Biochem/physiol Actions

Protein Target: MKK6
Target Sub-Family: STE

Quality

routinely evaluated by phosphorylation of MBP

Physical form

affinity chromatography on amylose resin beads

Storage and Stability

6 months at -70C

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Sens. 1

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Dominic Fortes
Acta crystallographica. Section E, Crystallographic communications, 71(Pt 7), 799-806 (2015-08-19)
Time-of-flight neutron powder diffraction data have been measured from ∼90 mol% deuterated isotopologues of Na2MoO4·2H2O and Na2WO4·2H2O at 295 K to a resolution of sin (θ)/λ = 0.77 Å(-1). The use of neutrons has allowed refinement of structural parameters with a precision that varies
Sandeep B Adavi et al.
Bio-protocol, 9(20), e3402-e3402 (2019-10-20)
Nitric oxide (NO), is a redox-active, endogenous signalling molecule involved in the regulation of numerous processes. It plays a crucial role in adaptation and tolerance to various abiotic and biotic stresses. In higher plants, NO is produced either by enzymatic
Romina Bertinat et al.
Journal of cellular physiology, 232(2), 355-362 (2016-10-31)
Diabetic kidney disease (DKD) is the major cause of end stage renal disease. Sodium tungstate (NaW) exerts anti-diabetic and immunomodulatory activities in diabetic animal models. Here, we used primary cultures of renal proximal tubule epithelial cells derived from type-2-diabetic (D-RPTEC)
Tianxiao Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(4) (2022-01-26)
Proinflammatory cytokine production by innate immune cells plays a crucial role in inflammatory diseases, but the molecular mechanisms controlling the inflammatory responses are poorly understood. Here, we show that TANK-binding kinase 1 (TBK1) serves as a vital regulator of proinflammatory
A Dominic Fortes
Acta crystallographica. Section E, Crystallographic communications, 71(Pt 6), 592-596 (2015-06-20)
Time-of-flight neutron powder diffraction data have been collected from Na2MoO4 and Na2WO4 to a resolution of sin (θ)/λ = 1.25 Å(-1), which is substanti-ally better than the previous analyses using Mo Kα X-rays, providing roughly triple the number of measured reflections with

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