Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

R8900

Sigma-Aldrich

Ro 8-4304

solid

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H23FN2O3 · HCl
Molecular Weight:
406.88
MDL number:
MFCD03101333
UNSPSC Code:
12352200
PubChem Substance ID:
24277971
NACRES:
NA.77

form

solid

solubility

H2O: ≤0.5 mg/mL

originator

Roche

storage temp.

2-8°C

SMILES string

Cl.NC(=O)c1ccc(OCCC(O)N2CCC(=CC2)c3ccc(F)cc3)cc1

InChI

1S/C21H23FN2O3.ClH/c22-18-5-1-15(2-6-18)16-9-12-24(13-10-16)20(25)11-14-27-19-7-3-17(4-8-19)21(23)26;/h1-9,20,25H,10-14H2,(H2,23,26);1H

InChI key

NYFXHCMXYODFLP-UHFFFAOYSA-N

Gene Information

human ... GRIN2B(2904)

Biochem/physiol Actions

NR2B-selective, noncompetitive NMDA glutamate receptor antagonist

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Shuai Huang et al.
Molecular plant, 9(12), 1620-1633 (2016-10-21)
Nucleotide-binding leucine-rich repeat (NLR) proteins serve as immune receptors in both plants and animals. To identify components required for NLR-mediated immunity, we designed and carried out a chemical genetics screen to search for small molecules that can alter immune responses
Ghelardini, C., et al.
Drug Development Research, 40, 251-258 (1997)
Neuronal nicotinic acetylcholine receptors as novel drug targets.
G K Lloyd et al.
The Journal of pharmacology and experimental therapeutics, 292(2), 461-467 (2000-01-20)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service