- Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend.
Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend.
Journal of controlled release : official journal of the Controlled Release Society (2002-05-07)
El-Refaie Kenawy, Gary L Bowlin, Kevin Mansfield, John Layman, David G Simpson, Elliot H Sanders, Gary E Wnek
PMID11992678
RÉSUMÉ
Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations.
MATÉRIAUX
Référence du produit
Marque
Description du produit
Référence
Conditionnement
Disponibilité
Prix
Quantité