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Merck

Beta-galactosidase catalyzed selective galactosylation of aromatic compounds.

Biotechnology progress (2006-02-04)
Nicolas Bridiau, Selma Taboubi, Nejib Marzouki, Marie Dominique Legoy, Thierry Maugard
RÉSUMÉ

A new approach to galacto-oligosaccharides and galacto-conjugates synthesis performed by the beta-galactosidase from Kluyveromyces lactis is reported. The enzymatic galactosylation of eight kinds of adsorbed aromatic primary alcohols, in particular the two drugs guaifenesin and chlorphenesin, gave the corresponding beta-D-galacto-pyranosides in yields ranging between approximately 10% and 96%. For the first time, we have showed that the adsorption of acceptor substrates onto solid supports such as silica gel influences the yield and the selectivity of galacto-conjugates synthesis. In particular, we observed that adsorption of acceptor favored the synthesis of digalactosylated compounds.

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Description du produit

Sigma-Aldrich
3-Aminobenzyl alcohol, 97%
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RéférenceRéf. du fournisseurConditionnementDisponibilitéPrixQuantité
BB20-7782A-250MG250 mg
Expédition sous 14 jour(s) - par un Aldrich Partner.
564,81 €
BB20-7782A-1G1 g
Expédition sous 14 jour(s) - par un Aldrich Partner.
1.146,30 €
BB20-7782A-2.5G2.5 g
Expédition sous 14 jour(s) - par un Aldrich Partner.
2.226,21 €