1612652
USP
Simethicone
United States Pharmacopeia (USP) Reference Standard
Synonyme(s) :
α-(Trimethylsilyl)-ω-methylpoly[oxy(dimethylsilylene)] mixture with silicon dioxide, Antifoam A, Antifoam AF
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About This Item
Produits recommandés
Qualité
pharmaceutical primary standard
Famille d'API
simethicone
Fabricant/nom de marque
USP
Application(s)
pharmaceutical (small molecule)
Format
neat
InChI
1S/C6H18O2Si2.O2Si/c1-7-10(5,6)8-9(2,3)4;1-3-2/h1-6H3;
Clé InChI
AMTWCFIAVKBGOD-UHFFFAOYSA-N
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Description générale
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide.
Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide.
Application
Simethicone USP reference standard suitable for use in specified USP compendial tests and assays.
Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph.
Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph.
Remarque sur l'analyse
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Autres remarques
Sales restrictions may apply.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Scandinavian journal of gastroenterology, 46(2), 227-235 (2010-10-28)
The value of supplemental use of Simethicone in endoscopy including capsule endoscopy (CE), colonoscopy and esophagogastroduodenoscopy is not addressed and is controversial. A systematic review and meta-analysis of randomized controlled studies on the use of Simethicone for endoscopy were carried
Suriya Keeratichananont et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 93(8), 892-897 (2010-08-20)
Simethicone improves endoscopic visibility and diagnostic accuracy during colonoscopy and capsule endoscopy. Nevertheless, there have been limited data on its usefulness in esophagogastroduodenoscopy (EGD). To evaluate the effectiveness of simethicone on enhancing endoscopic visibility in patients undergoing EGD. 121 patients
Krystyna Mojsiewicz-Pieńkowska
Journal of pharmaceutical and biomedical analysis, 58, 200-207 (2011-10-04)
The pharmaceutical industry is one of the more important sectors for the use of polydimethylsiloxanes (PDMS), which belong to the organosilicon polymers. In drugs for internal use, they are used as an active pharmaceutical ingredient (API) called dimeticone or simeticone.
A Gallo et al.
Minerva medica, 102(2), 133-139 (2011-04-13)
Management of functional dyspepsia is still controversial. Different controlled trials reported a superiority of prokinetics, H2-receptor antagonists and proton-pump inhibitors over placebo; nevertheless, symptomatic improvement after therapy is often incomplete and some of these drugs possess serious side effects. The
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