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PRS3627

Sigma-Aldrich

Anti-LAMP-2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Lysosomal-associated membrane protein 2

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About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Conjugué:
unconjugated
application:
ELISA (i)
ICC
WB
Clone:
polyclonal
Espèces réactives:
mouse, human
citations:
13
Technique(s):
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Source biologique

rabbit

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, human

Technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Comparer avec des articles similaires

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Montrer les différences

1 of 4

Cet article
L1418L0668L0419
antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

CY3 conjugate

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

Gene Information

mouse ... Lamp2(16784)

Gene Information

human ... LAMP1(3916)
mouse ... Lamp1(16783)
rat ... Lamp1(25328)

Gene Information

human ... LAMP2(3920)
mouse ... Lamp2(16784)
rat ... Lamp2(24944)

Gene Information

human ... LAMP1(3916)
mouse ... Lamp1(16783)
rat ... Lamp1(25328)

Description générale

Lamp2 (lysosome-associated membrane protein gene)is located in the lysosomal lumen and lysosomal membrane. However upon chronic acidosis in the tumour microenvironment, it is found to be present in the plasma membrane.

Immunogène

a 17 amino acid peptide from near the center of human LAMP-2.

Application

Anti-LAMP-2 antibody has been used in immunofluorescence and western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Actions biochimiques/physiologiques

LAMP2 (lysosome-associated membrane protein gene) preserves lysosomal membranes from acid proteolysis. It serves as an acidity biomarker in spheroids and xenografts. It also has some role in maturation of autophagic vacuoles and cell-cell or cell-extracellular matrix adhesion. Reduction of LAMP2 (lysosome-associated membrane protein gene) can increase acidosis-mediated toxicity. Mutation in LAMP2 can cause cardiomyopathy in young patients.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3627.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Damaghi M, et al.
Nature Communications, 6:8752 (2015)
Effects of white light-emitting diode (LED) exposure on retinal pigment epithelium in vivo
Jaadane I, et al.
Journal of Cellular and Molecular Medicine (2017)
Unique properties of lamp2a compared to other lamp2 isoforms
Cuervo AM and Dice JF
Journal of Cell Science, 113 Pt 24, 4441-4450 (2000)
Imene Jaadane et al.
Journal of cellular and molecular medicine, 21(12), 3453-3466 (2017-07-01)
Ageing and alteration of the functions of the retinal pigment epithelium (RPE) are at the origin of lost of vision seen in age-related macular degeneration (AMD). The RPE is known to be vulnerable to high-energy blue light. The white light-emitting
Tobias Boothe et al.
Molecular metabolism, 5(5), 366-378 (2016-04-26)
The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was to determine the

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