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  • Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8.

Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8.

Oncogene (2015-03-10)
Y Jiang, B Yan, W Lai, Y Shi, D Xiao, J Jia, S Liu, H Li, J Lu, Z Li, L Chen, X Chen, L Sun, K Muegge, Y Cao, Y Tao
ZUSAMMENFASSUNG

Epstein-Barr virus (EBV) causes human lymphoid malignancies, and the EBV product latent membrane protein 1 (LMP1) has been identified as an oncogene in epithelial carcinomas such as nasopharyngeal carcinoma (NPC). EBV can epigenetically reprogram lymphocyte-specific processes and induce cell immortalization. However, the interplay between LMP1 and the NPC host cell remains largely unknown. Here, we report that LMP1 is important to establish the Hox gene expression signature in NPC cell lines and tumor biopsies. LMP1 induces repression of several Hox genes in part via stalling of RNA polymerase II (RNA Pol II). Pol II stalling can be overcome by irradiation involving the epigenetic regulator TET3. Furthermore, we report that HoxC8, one of the genes silenced by LMP1, has a role in tumor growth. Ectopic expression of HoxC8 inhibits NPC cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes. We propose that viral latency products may repress via stalling key mediators that in turn modulate glycolysis.

MATERIALIEN
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Sigma-Aldrich
Formaldehyd -Lösung, for molecular biology, 36.5-38% in H2O
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EN300-1719793-50MG50 mg
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EN300-1719793-100MG100 mg
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308.560,00 HUF
EN300-1719793-250MG250 mg
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432.554,00 HUF
EN300-1719793-500MG500 mg
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672.638,00 HUF
EN300-1719793-1G1 g
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857.394,00 HUF
EN300-1719793-2.5G2.5 g
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1.664.096,00 HUF
EN300-1719793-5G5 g
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2.453.508,00 HUF
EN300-1719793-10G10 g
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3.630.710,00 HUF
SAFC
Formaldehyd -Lösung, contains 10-15% methanol as stabilizer, 37 wt. % in H2O
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EN300-1719793-50MG50 mg
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239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
857.394,00 HUF
EN300-1719793-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
1.664.096,00 HUF
EN300-1719793-5G5 g
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2.453.508,00 HUF
EN300-1719793-10G10 g
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3.630.710,00 HUF
Sigma-Aldrich
Formaldehyd -Lösung, for molecular biology, BioReagent, ≥36.0% in H2O (T)
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EN300-1719793-50MG50 mg
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239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
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857.394,00 HUF
EN300-1719793-2.5G2.5 g
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1.664.096,00 HUF
EN300-1719793-5G5 g
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2.453.508,00 HUF
EN300-1719793-10G10 g
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3.630.710,00 HUF
Supelco
Formaldehyd -Lösung, stabilized with methanol, ~37 wt. % in H2O, certified reference material
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EN300-1719793-50MG50 mg
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239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
857.394,00 HUF
EN300-1719793-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
1.664.096,00 HUF
EN300-1719793-5G5 g
Versand in 14 Tagen - ab Aldrich Partner.
2.453.508,00 HUF
EN300-1719793-10G10 g
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3.630.710,00 HUF
Sigma-Aldrich
Normales Maus-IgG, Normal Mouse IgG Polyclonal Antibody control validated for use in Immunoprecipitation & Western Blotting.
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EN300-1719793-50MG50 mg
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239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
857.394,00 HUF
EN300-1719793-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
1.664.096,00 HUF
EN300-1719793-5G5 g
Versand in 14 Tagen - ab Aldrich Partner.
2.453.508,00 HUF
EN300-1719793-10G10 g
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3.630.710,00 HUF
Sigma-Aldrich
Formaldehyd -Lösung, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
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EN300-1719793-50MG50 mg
Versand in 14 Tagen - ab Aldrich Partner.
239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
857.394,00 HUF
EN300-1719793-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
1.664.096,00 HUF
EN300-1719793-5G5 g
Versand in 14 Tagen - ab Aldrich Partner.
2.453.508,00 HUF
EN300-1719793-10G10 g
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3.630.710,00 HUF
Sigma-Aldrich
Formaldehyd -Lösung, meets analytical specification of USP, ≥34.5 wt. %
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EN300-1719793-50MG50 mg
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239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
857.394,00 HUF
EN300-1719793-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
1.664.096,00 HUF
EN300-1719793-5G5 g
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2.453.508,00 HUF
EN300-1719793-10G10 g
Versand in 14 Tagen - ab Aldrich Partner.
3.630.710,00 HUF
Sigma-Aldrich
Formaldehyd-12C -Lösung, 20% in H2O, 99.9 atom % 12C
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EN300-1719793-50MG50 mg
Versand in 14 Tagen - ab Aldrich Partner.
239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
857.394,00 HUF
EN300-1719793-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
1.664.096,00 HUF
EN300-1719793-5G5 g
Versand in 14 Tagen - ab Aldrich Partner.
2.453.508,00 HUF
EN300-1719793-10G10 g
Versand in 14 Tagen - ab Aldrich Partner.
3.630.710,00 HUF
Sigma-Aldrich
Anti-HOXC8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
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EN300-1719793-50MG50 mg
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239.894,00 HUF
EN300-1719793-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
308.560,00 HUF
EN300-1719793-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
432.554,00 HUF
EN300-1719793-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
672.638,00 HUF
EN300-1719793-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
857.394,00 HUF
EN300-1719793-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
1.664.096,00 HUF
EN300-1719793-5G5 g
Versand in 14 Tagen - ab Aldrich Partner.
2.453.508,00 HUF
EN300-1719793-10G10 g
Versand in 14 Tagen - ab Aldrich Partner.
3.630.710,00 HUF