Direkt zum Inhalt
Merck
  • Impact of hydrophobic chain composition on amphiphilic macromolecule antiatherogenic bioactivity.

Impact of hydrophobic chain composition on amphiphilic macromolecule antiatherogenic bioactivity.

Biomacromolecules (2014-07-30)
Allison Faig, Latrisha K Petersen, Prabhas V Moghe, Kathryn E Uhrich
ZUSAMMENFASSUNG

Amphiphilic macromolecules (AMs) composed of sugar backbones modified with branched aliphatic chains and a poly(ethylene glycol) (PEG) tail can inhibit macrophage uptake of oxidized low-density lipoproteins (oxLDL), a major event underlying atherosclerosis development. Previous studies indicate that AM hydrophobic domains influence this bioactivity through interacting with macrophage scavenger receptors, which can contain basic and/or hydrophobic residues within their binding pockets. In this study, we compare two classes of AMs to investigate their ability to promote athero-protective potency via hydrogen-bonding or hydrophobic interactions with scavenger receptors. A series of ether-AMs, containing methoxy-terminated aliphatic arms capable of hydrogen-bonding, was synthesized. Compared to analogous AMs containing no ether moieties (alkyl-AMs), ether-AMs showed improved cytotoxicity profiles. Increasing AM hydrophobicity via incorporation of longer and/or alkyl-terminated hydrophobic chains yielded macromolecules with enhanced oxLDL uptake inhibition. These findings indicate that hydrophobic interactions and the length of AM aliphatic arms more significantly influence AM bioactivity than hydrogen-bonding.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Diethylether, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Diethylether, suitable for HPLC, ≥99.9%, inhibitor-free
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Diethylether, ACS reagent, anhydrous, ≥99.0%, contains BHT as inhibitor
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Poly(tetrafluorethylen), powder (free-flowing), 1 μm particle size
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Diethylether
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Poly(tetrafluorethylen), powder, >40 μm particle size
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Poly(tetrafluorethylen), powder, 200 μm particle size
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Poly(tetrafluorethylen), powder, 35 μm particle size
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Poly(tetrafluorethylen), beads
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Supelco
Diethylether, analytical standard
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Poly(tetrafluorethylen), powder, ≥350 μm particle size
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
Poly(tetrafluorethylen), powder (free-flowing), ≤12 μm particle size
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge
Sigma-Aldrich
D-(−)-Weinsäure-dibenzylester, ≥98.0% (sum of enantiomers, HPLC)
SKU
Packungsgröße
Verfügbarkeit
Preis
Menge