Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ZUSAMMENFASSUNG

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

298093

Sigma-Aldrich

Platin, gauze, 100 mesh, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinschwarz, black, powder, ≤20 μm, ≥99.95% trace metals basis

327492

Sigma-Aldrich

Platin, wire, diam. 1.0 mm, 99.9% trace metals basis

267201

Sigma-Aldrich

Platin, wire, diam. 0.5 mm, 99.99% trace metals basis

267244

Sigma-Aldrich

Platin, foil, thickness 0.025 mm, 99.9% trace metals basis

204013

Sigma-Aldrich

Platin, powder, 99.995% trace metals basis

349402

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, 99.9% trace metals basis

298107

Sigma-Aldrich

Platin, gauze, 52 mesh, 99.9% trace metals basis

685453

Sigma-Aldrich

Platin, nanopowder, <50 nm particle size (TEM)

267228

Sigma-Aldrich

Platin, wire, diam. 0.5 mm, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinschwarz, fuel cell grade, ≥99.9% trace metals basis

349356

Sigma-Aldrich

Platin, foil, thickness 0.05 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platin, wire, diam. 2.0 mm, 99.9% trace metals basis

357367

Sigma-Aldrich

Platin, wire, diam. 0.10 mm, 99.99% trace metals basis

GF49364264

Platin, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

520799

Sigma-Aldrich

Platinschwarz, low bulk density, ≥99.9% trace metals basis

GF98759200

Platin, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

373265

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, thermocouple grade

771937

Sigma-Aldrich

Platin, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

349321

Sigma-Aldrich

Platin, foil, thickness 0.25 mm, 99.99% trace metals basis

267171

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, 99.99% trace metals basis

GF21250594

Platin, tube, 100mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%

349372

Sigma-Aldrich

Platin, foil, thickness 1.0 mm, 99.99% trace metals basis

GF90182257

Platin, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%

267163

Sigma-Aldrich

Platin, wire, diam. 0.127 mm, 99.99% trace metals basis

GF72819715

Platin, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%

GF17703930

Platin, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.99+%

GF80394914

Platin, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.99+%

GF02251730

Platin, rod, 200mm, diameter 1.0mm, 99.95%

GF35428406

Platin, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%