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  • A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.

A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.

Organic & biomolecular chemistry (2013-03-15)
Meng Wang, Cun Tan, Qian He, Yuyuan Xie, Chunhao Yang
PMID23487245
ZUSAMMENFASSUNG

A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
P50803
Sigma-Aldrich
Propargylalkohol, 99%
203939
Sigma-Aldrich
Palladium, powder, 99.995% trace metals basis
326666
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Palladium, powder, <1 μm, ≥99.9% trace metals basis
203998
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Palladium, powder or granules, 99.99% trace metals basis
686468
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Palladium, nanopowder, <25 nm particle size (TEM), ≥99.5%
267120
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Palladium, foil, thickness 0.025 mm, 99.9% trace metals basis
464651
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Palladium, powder, <75 μm, 99.9% trace metals basis
267082
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Palladium, sponge, 99.9% trace metals basis
348694
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Palladium, wire, diam. 0.5 mm, 99.9% trace metals basis
348678
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Palladium, foil, thickness 1.0 mm, 99.9% trace metals basis
267112
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Palladium, wire, diam. 1.0 mm, 99.9% trace metals basis
287474
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Palladium, foil, thickness 0.5 mm, 99.9% trace metals basis
348643
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Palladium, foil, thickness 0.25 mm, 99.98% trace metals basis
373206
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Palladium, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis