- Copper(I)-catalyzed intramolecular O-arylation for the synthesis of 2,3,4,9-tetrahydro-1H-xanthen-1-ones with low loads of CuCl.
Copper(I)-catalyzed intramolecular O-arylation for the synthesis of 2,3,4,9-tetrahydro-1H-xanthen-1-ones with low loads of CuCl.
The Journal of organic chemistry (2012-10-17)
Kavitha Sudheendran, Chandi C Malakar, Jürgen Conrad, Uwe Beifuss
PMID23067231
ZUSAMMENFASSUNG
As little as 0.5 mol % CuCl is sufficient to catalyze the intramolecular O-arylation of easily accessible 2-(2-bromobenzyl)cyclohexane-1,3-diones to provide the corresponding 2,3,4,9-tetrahydro-1H-xanthen-1-ones with yields ranging from 83% to 99%.
MATERIALIEN