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Merck

A short overview on the medicinal chemistry of (-)-shikimic acid.

Mini reviews in medicinal chemistry (2012-07-26)
Amalia M Estévez, Ramón J Estévez
ZUSAMMENFASSUNG

Shikimic acid, a natural compound is a key intermediate in the biosynthesis of amino acids. Consequently, this derivative is widely present in many plants and has interesting biological properties. But besides the pharmacological relevance of shikimic acid itself, it is also an intermediate in the synthesis of many drugs, being the most relevant the antiviral agent oseltamivir (Tamiflu™). Here we present a short overview on recent natural, biotechnological and synthetical sources of shikimic acid, togheter with pharmacological applications of this compound and a selection of derivatives, including oseltamivir (Tamiflu™).

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Sigma-Aldrich
Shikimisäure, ≥99%
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Supelco
Shikimisäure, analytical standard
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