Direkt zum Inhalt
Merck

Nitric oxide as a source for bacterial triazole biosynthesis.

Nature communications (2020-04-03)
Guiyun Zhao, Yuan-Yang Guo, Shunyu Yao, Xinjie Shi, Longxian Lv, Yi-Ling Du
ZUSAMMENFASSUNG

The heterocycle 1,2,3-triazole is among the most versatile chemical scaffolds and has been widely used in diverse fields. However, how nature creates this nitrogen-rich ring system remains unknown. Here, we report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine. We reveal that its triazole moiety can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is used as a building block. These results expand our knowledge of the physiological role of nitric oxide synthase in building natural products with a nitrogen-nitrogen bond, and should also inspire the development of synthetic biology approaches for triazole production.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Diethylamin-NONOat Diethylammoniumsalz, ≥98%
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
SKULieferanten-SKUPackungsgrößeVerfügbarkeitPreisMenge
EN300-6477927-100MG100 mg
Versand in 14 Tagen - ab Aldrich Partner.
444,10 €
EN300-6477927-250MG250 mg
Versand in 14 Tagen - ab Aldrich Partner.
613,10 €
EN300-6477927-500MG500 mg
Versand in 14 Tagen - ab Aldrich Partner.
940,70 €
EN300-6477927-1G1 g
Versand in 14 Tagen - ab Aldrich Partner.
1.194,20 €
EN300-6477927-2.5G2.5 g
Versand in 14 Tagen - ab Aldrich Partner.
2.296,60 €
EN300-6477927-5G5 g
Versand in 14 Tagen - ab Aldrich Partner.
3.376,90 €