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  • Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation.

Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation.

Molecular systems biology (2017-04-05)
Kristina N-M Daeffler, Jeffrey D Galley, Ravi U Sheth, Laura C Ortiz-Velez, Christopher O Bibb, Noah F Shroyer, Robert A Britton, Jeffrey J Tabor
PMID28373240
ABSTRACT

There is a groundswell of interest in using genetically engineered sensor bacteria to study gut microbiota pathways, and diagnose or treat associated diseases. Here, we computationally identify the first biological thiosulfate sensor and an improved tetrathionate sensor, both two-component systems from marine