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  • The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.

Bioorganic & medicinal chemistry letters (2002-07-20)
Richard J Sciotti, Marina Pliushchev, Paul E Wiedeman, Darlene Balli, Robert Flamm, Angela M Nilius, Kennan Marsh, DeAnne Stolarik, Robert Jolly, Roger Ulrich, Stevan W Djuric
PMID12127518
ABSTRACT

A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.