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  • Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA.

Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA.

Chemical communications (Cambridge, England) (2012-05-17)
Xiaofeng Wei, Wenlie Lin, Na Ma, Fang Luo, Zhenyu Lin, Longhua Guo, Bin Qiu, Guonan Chen
PMID22590712
ABSTRACT

Based on the specific folic acid-folate receptor (FA-FR) interaction, macromolecular FR can bind with FA-linked DNA-small molecule chimeras, which can prevent enzymolysis by exonuclease III (Exo III), enabling a novel fluorescence biosensor for FR to be developed using quinaldine red as a G-quadruplex-binding probe.