GHRT-89HK

Human Ghrelin (TOTAL) RIA

• UNSPSC Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

Properties

• grade: for protein analysis
• Quality Level: 100
• description: ED₈₀ = 395 ± 88 pg/mL ED₅₀ = 895 ± 177 pg/mL ED₂₀ = 2015 ± 382 pg/mL ; analytes available: Ghrelin
• feature: accuracy 90–96%
• species reactivity: human
• sensitivity measuring range: 100-10000 pg/mL
• technique(s): radioimmunoassay: suitable
• UniProt accession no.: Q9UBU3
• detection method: radioactive

Description

General description

FUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.

Application

Two-day disequilibrium assay at 4°C. Sample volume: ≤ 100 μL Plasma (collected on ice) recommended

Analysis Note

Linearity 99–146%

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS02,GHS06,GHS09
• Signal Word: Danger
• Hazard Statements: H226,H302 + H332,H311,H319,H336,H411
• Precautionary Statements: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Flam. Liq. 3 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 3 - Flammable liquids