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Merck

CYP2C9

cytochrome P450, family 2, subfamily C, polypeptide 9

Synonyms:
CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
Species:
UniProtKB ID:
Gene ID:
  • Human(1559) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CYP2C9 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
MONOCLONAL ANTI-CYP2C9 (N-TERMINAL) antibody produced in mouse, crude ascites, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
(S)-(−)-Warfarin, ≥97% (HPLC),
Species
human
Thiabendazole, suitable for plant cell culture,
Species
human
Thiabendazole, ≥99%, powder,
Species
human
3,3′-Methylene-bis(4-hydroxycoumarin), ,
Species
human
Benzbromarone, analytical standard,
Species
human

Proteins

Product Number
Description
Species
Cytochrome P450 2C9*3 (I359L), human, recombinant, expressed in E. coli,
Species
human
Cytochrome P450 2C9*2 (R144C), human, recombinant, expressed in E. coli,
Species
human
CypExpress 2C9 Cytochrome P450 human, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CYP2C9,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
Tolbutamide, analytical standard,
Species
human, mouse