SRP6516
Albumin from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Albumin protein, human Albumin, human Albumin protein, human plasma, human plasma Albumin proteinHSA, native Albumin, native Albumin protein
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General description
Human albumin is encoded by ALB gene that is mapped to human chromosome 4q. The gene is developmentally regulated and is synthesized by the liver. The encoded protein has a molar mass of 65,000 Da and consists of a single polypeptide chain of 585 amino acids.
Application
Albumin has been used in ion exchange chromatography to compare the albumin isolated from whole human plasma. It has been used to bind to phage clones in phage binding assay.
Biochem/physiol Actions
Human albumin is a globular unglycosylated serum protein that makes up for more than half of the total plasma or serum proteins. It functions in the maintenance of COP (cellular oncotic pressure). It binds to hydrophobic organic anions such as, bilirubin, long-chain fatty acids and haematin and some cations such as magnesium and calcium. It also serves as a secondary or tertiary carrier for steroids, vitamin D and thyroxine. It is involved in the catabolism of prostaglandins and metabolism of certain endogenous substances, such as lipids, and eicosanoids. It acts as a plasma buffer and scavenges oxygen free radicals, thus reducing the pathological effects of certain inflammatory diseases. Mutation in the gene coding for albumin leads to familial dysalbuminaemic hyperthyroidism.
Physical form
Lyophilized as a salt free solid.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1A
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4.
Minghetti PP
The Journal of Biological Chemistry, 261, 6747-6757 (1986)
Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma.
Travis J
The Biochemical Journal, 157, 301-306 (1976)
Albumin binding as a general strategy for improving the pharmacokinetics of proteins.
Dennis MS
The Journal of Biological Chemistry, 277, 35035-35043 (2002)
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Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic valves. However, whether zinc directly regulates CAVD is yet to be elucidated.
The role of albumin in critical illness.
Nicholson JP
British Journal of Anaesthesia, 85, 599-610 (2000)
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