SML2437

H-151

≥98% (HPLC), STING protein antagonist, powder

• Synonym(s): 1-(4-Ethylphenyl)-3-(1H-indol-3-yl) urea
• Empirical Formula (Hill Notation): C₁₇H₁₇N₃O
• CAS Number: 941987-60-6
• Molecular Weight: 279.34
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD08026581
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: H-151, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(c(c1)NC(=O)Nc3ccc(cc3)CC)cccc2
• InChI: 1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
• InChI key: UJZDIKVQFMCLBE-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Antagonist of the stimulator of interferon genes (STING) protein

H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to have a pathogenic role in some inflammatory diseases. H-151 is a potent and selective STING antagonist with inhibitory activity both in human cells and in vivo in mice. Given as a pretreatment, H-151 was shown to attenuate pathological features of autoinflammatory disease in mouse models, reducing systemic cytokine responses in mice treated with the STING agonist 10-carboxymethyl-9-acridanone (CMA)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable