SML0146

ZL006

≥98% (HPLC)

• Synonym(s): 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
• Empirical Formula (Hill Notation): C₁₄H₁₁Cl₂NO₄
• CAS Number: 1181226-02-7
• Molecular Weight: 328.15
• NACRES: NA.25
• PubChem Substance ID: 329825194
• UNSPSC Code: 12352200
• MDL number: MFCD20527326
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥5 mg/mL (warmed to 60° C)
• storage temp.: 2-8°C
• SMILES string: OC1=C(Cl)C=C(Cl)C=C1CNC(C=C2)=CC(O)=C2C(O)=O
• InChI: 1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)
• InChI key: RTEYSQSXRFVKTJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Inhibitor of nNOS-PSD-95 interaction

ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke.

ZL006, a novel neuroprotectant, is also called as 5-(3, 5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid. It has the ability to block the interaction of neuronal nitric oxide synthase (nNOS)/postsynaptic density protein-95 (PSD-95) in co-immunoprecipitation assays of extracts from glutamate or cultured neurons and cortical brain, stimulated by ischemia.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3