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375095

Heparin, Sodium Salt, Porcine Intestinal Mucosa

Synonym(s):

Heparin, Sodium Salt, Porcine Intestinal Mucosa, HEP, Na

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About This Item

CAS Number:
9041-08-1
UNSPSC Code:
12352201
NACRES:
NA.79
MDL number:
MFCD00081689
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description

Merck USA index - 14, 4653

Quality Segment

100

form

lyophilized

specific activity

≥180 USP units/mg dry wt

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

15-25°C

SMILES string

[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O

InChI

1S/C26H42N2O37S5.Na/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36;/h5-20,23-26,28-29,31-

InChI key

JRTRSJGZMRQDHI-UHFFFAOYSA-N

General description

MW: 15,000 - 19,000 Da
Preservative-free, non-sterile. Highly sulfated dextrorotatory mucopolysaccharide with specific anticoagulant properties. Inhibits IP3-activated Ca2+ channel release of the endoplasmic reticulum. Reported to activate the ryanodine receptor. MW: 15,000 - 19,000 Da.

Other Notes

Seuwen, K., and Boddeke, H.G. 1995. Br. J. Pharmacol.114, 1613.
Ehrlich, B.E., et al. 1994. Trends Pharmacol. Sci.15,145.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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1 of 1

This Item
H3393H4784PHR8927
Heparin, Sodium Salt, Porcine Intestinal Mucosa

Millipore

375095

Heparin, Sodium Salt, Porcine Intestinal Mucosa

Heparin sodium salt from porcine intestinal mucosa Grade I-A, ≥180 USP units/mg

Sigma-Aldrich

H3393

Heparin sodium salt from porcine intestinal mucosa

Heparin sodium salt from porcine intestinal mucosa ≥180 USP units/mg

Sigma-Aldrich

H4784

Heparin sodium salt from porcine intestinal mucosa

Heparin sodium pharmaceutical secondary standard, certified reference material

Supelco

PHR8927

Heparin sodium

solubility

water: 50 mg/mL

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

solubility

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

300

form

lyophilized

form

powder

form

powder

form

-

storage temp.

15-25°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-10 to -25°C

shipped in

ambient

shipped in

-

shipped in

-

shipped in

-

description

Merck USA index - 14, 4653

description

-

description

-

description

-

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Questions

1–2 of 2 Questions  

  1. I plan to use heparin in Neurobasal medium for culturing GBM cells. Literature suggests 2 µg/mL, but I need the units/mL for the final concentration. Could you provide guidance on the correct units/mL for heparin?

    1 answer

    1. Product 375095 is assayed for activity on a batch to batch basis with a specification for this product ≥160 USP units/mg dry weight. The reported activity value for this product will be found on the certificate of analysis for a given lot. It is unclear as to what activity corresponds to the provided concentration that was indicated and only the authors of the literature citation would know. Certain research articles do provide information on the activity of heparin to supplement neurobasal medium (NBM). Please see the article below which states NBM can be supplemented with 100 U/uL heparin. This decision will be at the discretion of the end user.

      https://www.sciencedirect.com/science/article/pii/S2666166723004884

      Helpful?

  2. What should be the storage temperature after 100 000 units of heparin salt is dissolved in 100 mL of PBS 1x

    1 answer

    1. Sterile filtered heparin solutions remain stable for up to 2 years when stored at 2-8 °C, provided th. Autoclaving and freezing heparin solutions are not recommended. Please see the link below to review additional information available in the datasheet for similar product H3393:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/112/608/h3393pis.pdf

      Helpful?

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