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218750

Caspase-3 Inhibitor III

The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase-3 Inhibitor III, Ac-DEVD-CMK

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Size/SKUAvailabilityPrice
1 mg
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$105.00
5 mg
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$441.00

About This Item

Empirical Formula (Hill Notation):
C21H31ClN4O11
CAS Number:
Molecular Weight:
550.94
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥98% (HPLC)
Form:
lyophilized solid, powder
Storage condition:
OK to freeze, desiccated

$105.00


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Quality Segment

assay

≥98% (HPLC)

form

lyophilized solid, powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white to off-white

solubility

20% acetonitrile: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O)C(C)C)CC(=O)O

InChI

1S/C21H31ClN4O11/c1-9(2)18(21(37)25-12(6-16(31)32)14(28)8-22)26-19(35)11(4-5-15(29)30)24-20(36)13(7-17(33)34)23-10(3)27/h9,11-13,18H,4-8H2,1-3H3,(H,23,27)(H,24,36)(H,25,37)(H,26,35)(H,29,30)(H,31,32)(H,33,34)/t11-,12-,13-,18-/m0/s1

InChI key

ATNOUPFYBMVFLD-RSLFNQERSA-N

General description

A potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.
A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Ac-Asp-Glu-Val-Asp-CMK
Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
235420218745218728
assay

≥98% (HPLC)

assay

≥90% (HPLC)

assay

-

assay

≥95% (HPLC)

form

lyophilized solid, powder

form

solid

form

semisolid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

20% acetonitrile: 1 mg/mL

solubility

DMSO: 5 mg/mL, water: soluble

solubility

DMSO: 5 mg/mL

solubility

water: 1 mg/mL, DMSO: 5 mg/mL

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated


Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificates of Analysis (COA)

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